Projects
Dry Lab
Wet Lab / Synthesis
Modeling stearoyl-coenzyme A desaturase 1 inhibitors to ameliorate α-Syn cytotoxicity in Parkinson's disease
Bridget Liu, Audrey Tsai, Darren DressenDOI: https://doi.org/10.59720/23-151
Keywords: SCD1, α-Synuclein, Parkinson's disease, molecular docking, small molecule inhibitors.
Abstract:
Parkinson's disease is a form of progressive neurodegeneration that primarily affects dopaminergic neurons. It is characterized by misfolded α-Synuclein (α-Syn) proteins clumped together in Lewy bodies. More recently, it has been proposed that α-Syn toxicity may increase during interactions with fatty acids. There have been several studies linking stearoyl-coenzyme A desaturase 1 (SCD1), the rate-limiting enzyme for the conversion of saturated fatty acids (SFAs) to monounsaturated fatty acids (MUFAs), to the increased toxicity of α-Syn. Consequently, SCD1 inhibition is shown to decrease the toxicity and aggregation of α-Syn. However, the precise interactions of SCD1 inhibitors and SCD1 are unclear. This project compared seven novel analogs of SCD1 inhibitors, which we hypothesized to compete with SCD1's coenzyme stearoyl coenzyme A, decreasing SFA conversion into their respective MUFAs. The analogs shared the same general pharmacophore with varying R groups (p-toluoyl, 4-fluorobenzoyl, 3-trifluoromethyl benzoyl, o-anisoyl, 3,4-difluorobenzoyl, 2-trifluoromethyl benzoyl, and 2-chlorobenzoyl). We hypothesized that analogs with the least steric hindrance would perform best. We drew a structure-activity relationship from in silico studies, with molecular docking results showing that four analogs were just as or more effective than MF-438, a commercially available SCD1 inhibitor. These results imply that the most effective R group was least sterically hindered, guiding further analog development in the field of small molecule Parkinson's disease cures.
Determining the Efficacy of Polyphenols in Inhibiting the Aggregation of Amyloid Beta Proteins
Gayathri Renganathan, Bridget Liu, Bhoomi Jain, Sumayyah Ismail, Kavya Patel, Ayush Patel, Alyssa Halvorsen, Nandini MannemDOI: https://doi.org/10.47611/jsrhs.v12i3.4848
Keywords: Polyphenols, Amyloid Beta proteins, Alzheimer's disease, Protein aggregation.
Abstract:
Alzheimer's Disease is caused by an aggregation of amyloid beta and tau proteins in the brain. Polyphenols, a broad class of naturally-existing compounds, have been shown to inhibit the aggregation of those proteins. This project aims to focus on expressing different combinations of those proteins, as well as assaying those proteins for aggregation inhibition using polyphenols such as curcumin, caffeic acid, epigallocatechin gallate (EGCG), and more to determine which polyphenol is most effective in doing so. We chose to use these polyphenols because of their past precedence in other work, along with their widespread prevalence. However, this project focused more on the biological and in-vitro aspect of polyphenols inhibiting amyloid beta, such as conducting multiple assays including Congo Red, Avoidance, and Dynamic Light Scattering in order to receive tangible results. Through our studies, we found that polyphenols do produce an inhibitory effect on the aggregation of amyloid-beta.
Investigated synthesis of analogs of rivastigmine to treat Alzheimer's
Bridget LiuKeywords: Rivastigmine, analog synthesis, Alzheimer's disease, SCCUR.
Abstract:
Investigated synthesis of analogs of rivastigmine to treat Alzheimer's. Presented at 2022 SCCUR.
LCMS Quantification of Neurotransmitters in Parkinson's
Bridget LiuKeywords: LCMS, neurotransmitters, quantification, Parkinson's disease, WCBSURC.
Abstract:
Led a project using LCMS to quantify neurotransmitters in Parkinson's. Presented at 2023 WCBSURC.
Fluorophore-Labeled Peptides Investigation
Bridget LiuKeywords: Fluorophore, labeled peptides, investigation, ACS.
Abstract:
Spearheaded a project investigating fluorophore-labeled peptides. Presented at 2023 Fall ACS.